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DSB (Dendritic Spine Beheader)

A Dragonfly 3D World plugin written at the Max Planck Florida Institute for Neuroscience. It provides a fast, semi-automatic method for separating dendritic spine heads from their respective spines on a neuron's dendrite. By separating the spine head, this tool allows a neuroscience researcher to quickly and accurately find the volume of a dendritic spine head.

Features

  • Preprocessing
    • Data preprocessing done automatically and saved to a .dsbv file for later use
  • Analysis
    • Automatically suggests a point to behead with easy human adjustment by dragging a slider, moving the beheading point along the spine
  • Visualization
    • Optionally visualize annotations labelling synapses for automatic inference of dendrite names
    • Optionally visualize the postsynaptic densities (PSDs) segmented to help understand where the synapse is on the dendritic spine
  • Output
    • Automatically CSV file with the dendritic spine head name and volume

Installation

Please view the installation guide

User Guide

Please view the user guide

About

A Dragonfly 3D World program to separate dendritic spine heads given a dendrite segmentation from serial electron microscopy data.

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