IFN-alpha

A multiscale QSP model of IFN-alpha induced activation of the JAK/STAT pathway in human liver cells ([1,2]).

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

References

[1] Kalra P, Brandl J, Gaub T, Niederalt C, Lippert J, Sahle S, et al. (2019) Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach. PLoS ONE 14(2): e0209587. https://doi.org/10.1371/journal.pone.0209587

[2] Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, et al. (2010) Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x