diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5b3ae6e6..2182937a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -9,6 +9,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - Added a BAM/CRAM conversion to FASTQ step to run tools that depend on FASTQ files. It still is advised to supply a FASTQ file if possible to reduce runtime of the pipeline. [#783](https://github.com/nf-core/rnafusion/pull/783)
 
+### Fixed
+
+- Fix issue with vcf_collect when no fusions are found by fusioninspector [#786](https://github.com/nf-core/rnafusion/pull/786)
+
 ## v4.0.0 - [2025-09-10]
 
 ### Added
diff --git a/bin/vcf_collect.py b/bin/vcf_collect.py
index 292c052f..437a1056 100755
--- a/bin/vcf_collect.py
+++ b/bin/vcf_collect.py
@@ -84,16 +84,14 @@ def vcf_collect(
     all_df = df.merge(
         gtf_df, how="left", left_on="CDS_LEFT_ID", right_on="Transcript_id"
     )
-    all_df[["PosA", "orig_start", "orig_end"]] = (
-        all_df[["PosA", "orig_start", "orig_end"]].fillna(0).astype(int)
-    )
 
     all_df = all_df[
         (
             (all_df["PosA"] >= all_df["orig_start"])
             & (all_df["PosA"] <= all_df["orig_end"])
         )
-        | ((all_df["orig_start"] == 0) & (all_df["orig_end"] == 0))
+        | ((all_df["orig_start"].isna()) & (all_df["orig_end"].isna()))
+        | (all_df["PosA"].isna())
     ]
 
     all_df["Left_transcript_version"] = all_df["CDS_LEFT_ID"].astype(str).str.split(".").str[-1]
@@ -145,21 +143,16 @@ def vcf_collect(
     all_df = all_df.merge(
         gtf_df, how="left", left_on="CDS_RIGHT_ID", right_on="Transcript_id"
     )
-    all_df[["PosB", "orig_start", "orig_end"]] = all_df[
-        ["PosB", "orig_start", "orig_end"]
-    ].fillna(0)
-    all_df[["PosB", "orig_start", "orig_end"]] = all_df[
-        ["PosB", "orig_start", "orig_end"]
-    ].astype(int)
+
     all_df = all_df[
         (
             (all_df["PosB"] >= all_df["orig_start"])
             & (all_df["PosB"] <= all_df["orig_end"])
         )
-        | ((all_df["orig_start"] == 0) & (all_df["orig_end"] == 0))
+        | ((all_df["orig_start"].isna()) & (all_df["orig_end"].isna()))
+        | (all_df["PosB"].isna())
     ]
 
-    all_df[["PosA", "PosB"]] = all_df[["PosA", "PosB"]].replace(0, np.nan)
     all_df = all_df.replace("", np.nan)
 
     all_df["Right_transcript_version"] = all_df["CDS_RIGHT_ID"].astype(str).str.split(".").str[-1]
@@ -213,6 +206,9 @@ def vcf_collect(
 
     all_df = all_df.combine_first(read_fusionreport_csv(fusionreport_csv))
 
+    # Filter out invalid entries with missing positional values
+    all_df = all_df[all_df["PosA"].notna() & all_df["PosB"].notna() & all_df["ChromosomeA"].notna() & all_df["ChromosomeB"].notna()]
+
     return write_vcf(column_manipulation(all_df), header_def(sample), out_file)
 
 
diff --git a/modules/local/vcf_collect/tests/main.nf.test.snap b/modules/local/vcf_collect/tests/main.nf.test.snap
index 1e203d0c..9b912c67 100644
--- a/modules/local/vcf_collect/tests/main.nf.test.snap
+++ b/modules/local/vcf_collect/tests/main.nf.test.snap
@@ -61,8 +61,8 @@
         ],
         "meta": {
             "nf-test": "0.9.2",
-            "nextflow": "25.04.6"
+            "nextflow": "25.10.2"
         },
-        "timestamp": "2025-08-12T20:45:25.283350308"
+        "timestamp": "2026-01-08T17:24:54.112204263"
     }
-}
+}
\ No newline at end of file