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docs: Colab notebook for full GPU pipeline run
End-to-end Colab notebook (notebooks/02_colab_run.ipynb) that produces a real cohort of PD-L1 binder designs with measured metrics. Workflow: 1. Install RFdiffusion + ProteinMPNN + ColabFold + BinderDiffuser 2. Download PDB 5O45, trim to chain B (PD-L1 IgV) 3. Generate 10 motif-scaffolded backbones with RFdiffusion 4. Design 4 sequences per backbone with ProteinMPNN 5. Re-fold each sequence with ColabFold (AF2 multimer) 6. Compute scRMSD, scTM, pLDDT, ipTM, pAE_interface 7. Filter, rank, render scatter and violin plots 8. Tarball and download artifacts Smoke-test parameters chosen to fit Colab's free T4 in under 30 minutes. Bump NUM_BACKBONES and SEQS_PER_BACKBONE for a larger run. Adds Colab launch badge, CI status badge, and license badge to README.
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**De novo protein binder design via motif-scaffolded diffusion + sequence design + structural validation.**
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[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/deepmind11/BinderDiffuser/blob/main/notebooks/02_colab_run.ipynb)
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[![CI](https://github.com/deepmind11/BinderDiffuser/actions/workflows/ci.yml/badge.svg)](https://github.com/deepmind11/BinderDiffuser/actions/workflows/ci.yml)
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[![License: MIT](https://img.shields.io/badge/License-MIT-yellow.svg)](LICENSE)
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![Hero](figures/hero.png)
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BinderDiffuser is an end-to-end pipeline for designing protein binders against

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