Created a very basic subtheme to test Open Framework for a client project. Copied page.tpl.php to the subtheme's templates folder. Switched the first sidebar to span4 instead of span3, and switched the main content to span8 instead of span9.
After clearing caches, I see the change for a brief flash on the prototype site, then it seems to rewrite to span3 somehow. Dummy text entered for testing appears as expected, so it is picking up the new page.tpl.php file correctly.
Error is viewable here: http://cpmcri.digitalraindrop.com/node